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Sequestration and microvascular congestion are associated with coma in human cerebral malaria.

Abstract:

The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood. Obstruction of the brain microvasculature because of sequestration of parasitized red blood cells (pRBCs) represents one mechanism that could contribute to coma in cerebral malaria. Quantitative postmortem microscopy of brain sections from Vietnamese adults dying of malaria confirmed that sequestration in the cerebral microvasculature was significantly higher in patients with cerebral malaria (CM; n = ...

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Publisher copy:
10.1093/infdis/jir812

Authors


Journal:
J Infect Dis More from this journal
Volume:
205
Issue:
4
Pages:
663-671
Place of publication:
United States
Publication date:
2012-02-15
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Language:
English
Keywords:
Pubs id:
pubs:258375
UUID:
uuid:914ca155-f1fd-4314-b92a-a7584ca95ae6
Local pid:
pubs:258375
Source identifiers:
258375
Deposit date:
2012-12-19

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