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cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies.

Abstract:

3'-5'-Cyclic adenosine monophosphate (cAMP) is a pleiotropic intracellular second messenger generated in response to activation of G(s) protein-coupled receptors. In the heart, cAMP mediates the catecholaminergic control on heart rate and contractility but, at the same time, it is responsible for the functional response to a wide variety of other hormones and neurotransmitters, raising the question of how the myocyte can decode the cAMP signal and generate the appropriate functional output to...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Journal:
British journal of pharmacology
Volume:
158
Issue:
1
Pages:
50-60
Publication date:
2009-09-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:91349e69-7645-47fd-aaf1-2c7ab7b0d57b
Source identifiers:
237796
Local pid:
pubs:237796

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