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Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants.

Abstract:

Although recent evidence suggests that the gas nitric oxide (NO) can modulate the secretion of corticotropin-releasing hormone (CRH) from acute rat hypothalamic explants, another gas, carbon monoxide (CO), has been suggested to play a role in neural signaling in the brain; CO may complement the activity of NO in long term potentiation. In this study, we have investigated whether CO shares with NO the ability to modify the release of CRH from the rat hypothalamus. Hemin, a specific CO precurso...

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Publication status:
Published

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Publisher copy:
10.1210/en.135.6.2314

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Journal:
Endocrinology
Volume:
135
Issue:
6
Pages:
2314-2317
Publication date:
1994-12-01
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
Source identifiers:
138491
Language:
English
Keywords:
Pubs id:
pubs:138491
UUID:
uuid:91196442-da7d-454e-9fcc-c46e471c5c68
Local pid:
pubs:138491
Deposit date:
2012-12-19

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