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Fitness loss under amino acid starvation in artemisinin-resistant Plasmodium falciparum isolates from Cambodia

Abstract:

Artemisinin is the most rapidly effective drug for Plasmodium falciparum malaria treatment currently in clinical use. Emerging artemisinin-resistant parasites pose a great global health risk. At present, the level of artemisinin resistance is still relatively low with evidence pointing towards a trade-off between artemisinin resistance and fitness loss. Here we show that artemisinin-resistant P. falciparum isolates from Cambodia manifested fitness loss, showing fewer progenies during the intr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-018-30593-5

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Role:
Author
ORCID:
0000-0002-0739-006X
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Funding agency for:
Bunditvorapoom, D
Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 12622
Publication date:
2018-08-22
Acceptance date:
2018-07-31
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:824670
URN:
uri:91173250-19ad-407c-be50-0b8fcd5978e6
UUID:
uuid:91173250-19ad-407c-be50-0b8fcd5978e6
Local pid:
pubs:824670

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