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Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster.

Abstract:

RNA silencing pathways are conserved gene regulation mechanisms that elicit decay and/or translational repression of mRNAs complementary to short interfering RNAs and microRNAs (miRNAs). The fraction of the transcriptome regulated by these pathways is not known, but it is thought that each miRNA may have hundreds of targets. To identify transcripts regulated by silencing pathways at the genomic level, we examined mRNA expression profiles in Drosophila melanogaster cells depleted of four Argon...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Natalin, P More by this author
Brennecke, J More by this author
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Journal:
Molecular and cellular biology
Volume:
26
Issue:
8
Pages:
2965-2975
Publication date:
2006-04-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:910badd6-df07-4d78-89e3-dfded622bc31
Source identifiers:
353653
Local pid:
pubs:353653

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