Journal article icon

Journal article

Cancer: pathological nuclear reprogramming?

Abstract:

The ability of stem cells to self-renew and generate different lineages during development and organogenesis is a fundamental, tightly controlled, and generally unidirectional process, whereas the 'immortality' of cancer cells could be regarded as pathological self-renewal. The molecular mechanisms that underpin the generation of induced pluripotent stem cells are remarkably similar to those that are deregulated in cancer - so much so that aberrant reprogramming is tumorigenic. The similariti...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nrc3781

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
Nature reviews. Cancer
Volume:
14
Issue:
8
Pages:
568-573
Publication date:
2014-08-05
DOI:
EISSN:
1474-1768
ISSN:
1474-175X
URN:
uuid:9108df71-2673-44a5-8464-ffb67ee01d23
Source identifiers:
476317
Local pid:
pubs:476317

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP