Journal article
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
- Abstract:
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Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5x10(-8)-1.2x10(-43)). Using a n...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 772.0KB)
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- Publisher copy:
- 10.1371/journal.pgen.1002607
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Authors
Funding
National Human Genome Research Institute
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Canadian Institutes of Health Research
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Canadian Foundation for Innovation
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Fonds de la recherche en sante du Quebec
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Ministere du Developpement economique
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS genetics Journal website
- Volume:
- 8
- Issue:
- 3
- Article number:
- e1002607
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
- Source identifiers:
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322832
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:322832
- UUID:
-
uuid:91016d81-3803-4c00-aa5c-1a3e43c054de
- Local pid:
- pubs:322832
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Dastani et al
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Dastani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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