- Abstract:
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Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5x10(-8)-1.2x10(-43)). Using a n...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 772.0kb)
-
- Publisher copy:
- 10.1371/journal.pgen.1002607
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- Funding agency for:
- Perry, JR
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS genetics Journal website
- Volume:
- 8
- Issue:
- 3
- Pages:
- Article: e1002607
- Publication date:
- 2012
- DOI:
- EISSN:
-
1553-7404
- ISSN:
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1553-7390
- URN:
-
uuid:91016d81-3803-4c00-aa5c-1a3e43c054de
- Source identifiers:
-
322832
- Local pid:
- pubs:322832
- Paper number:
- 3
- Language:
- English
- Keywords:
- Copyright holder:
- Dastani et al.
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Dastani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
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+ Sir Henry Wellcome Postdoctoral Research Fellow
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National Institutes of Health
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National Institute on Aging
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The Netherlands Organisation for Scientific Research
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Erasmus Medical Center
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