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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Abstract:

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5x10(-8)-1.2x10(-43)). Using a n...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1002607

Authors


Dastani, Z More by this author
Hivert, MF More by this author
Timpson, N More by this author
More by this author
Institution:
University of Oxford
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National Institutes of Health More from this funder
National Institute on Aging More from this funder
The Netherlands Organisation for Scientific Research More from this funder
Erasmus Medical Center More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
8
Issue:
3
Pages:
Article: e1002607
Publication date:
2012
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:91016d81-3803-4c00-aa5c-1a3e43c054de
Source identifiers:
322832
Local pid:
pubs:322832
Paper number:
3

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