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Journal article

Hypoxic regulation of osteoclast differentiation and bone resorption activity

Abstract:

Bone integrity is maintained throughout life via the homeostatic actions of bone cells, namely, osteoclasts, which resorb bone, and osteoblasts, which produce bone. Disruption of this balance in favor of osteoclast activation results in pathological bone loss, which occurs in conditions including osteoporosis, rheumatoid arthritis, primary bone cancer, and cancer metastasis to bone. Hypoxia also plays a major role in these conditions, where it is associated with disease progression and poor p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2147/HP.S95960

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Rosetrees Trust More from this funder
National Institute of Health Research More from this funder
Arthritis Research UK More from this funder
Publisher:
Dove Medical Press Publisher's website
Journal:
Hypoxia Journal website
Volume:
2015
Issue:
3
Pages:
73-82
Publication date:
2015-11-01
Acceptance date:
2015-10-07
DOI:
EISSN:
2324-1128
Source identifiers:
610164
Keywords:
Pubs id:
pubs:610164
UUID:
uuid:90f9777d-cf0a-4e90-b99f-42369bc4b1e0
Local pid:
pubs:610164
Deposit date:
2016-03-15

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