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Insights into the pre-initiation events of bacteriophage Φ6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex

Abstract:

The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. In order to initiate RNA polymerization, viral RdRPs must be able to interact with the incoming 3’ terminus of the template and position it, so that a productive binary complex is formed. Structural studies have revealed that RdRPs of dsRNA viruses that lack helicases have electrostatically charged areas on the polymerase surface, which might facilitate such interact...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkn1035

Authors


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Institution:
"University of Helsinki, Finland"
Department:
Department of Biological and Environmental Sciences
More by this author
Institution:
"University of Helsinki, Finland"
Department:
Department of Biological and Environmental Sciences
More by this author
Institution:
"University of Helsinki, Finland"
Department:
Department of Biological and Environmental Sciences
More by this author
Institution:
"University of Helsinki, Finland"
Department:
Department of Biological and Environmental Sciences
More by this author
Institution:
"University of Helsinki, Finland"
Department:
Department of Biological and Environmental Sciences
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Funding agency for:
David I. Stuart
More from this funder
Funding agency for:
Dennis H. Bamford
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
37
Issue:
4
Pages:
1182-1192
Publication date:
2009-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:90f0ce18-2ac0-44e5-8e84-d3337362d288
Local pid:
ora:2809
Language:
English
Subjects:

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