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Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway.

Abstract:

The small GTPase Rap1 is required for proper cell-cell junction formation and also plays a key role in mediating cAMP-induced tightening of adherens junctions and subsequent increased barrier function of endothelial cells. To further study how Rap1 controls barrier function, we performed quantitative global phosphoproteomics in human umbilical vein endothelial cells (HUVECs) prior to and after Rap1 activation by the Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP-AM (007-AM). Tryptic digests w...

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Publication status:
Published

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Publisher copy:
10.1039/c3mb25524g

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Journal:
Molecular bioSystems More from this journal
Volume:
9
Issue:
4
Pages:
732-749
Publication date:
2013-04-01
DOI:
EISSN:
1742-2051
ISSN:
1742-206X

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