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Learning about pain: the neural substrate of the prediction error for aversive events.

Abstract:

Associative learning is thought to depend on detecting mismatches between actual and expected experiences. With functional magnetic resonance imaging (FMRI), we studied brain activity during different types of mismatch in a paradigm where contrasting-colored lights signaled the delivery of painful heat, nonpainful warmth, or no stimulation. When painful heat stimulation was unexpected, there was increased FMRI signal intensity in areas of the hippocampus, superior frontal gyrus, cerebellum, a...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.160266497

Authors


Ploghaus, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
16
Pages:
9281-9286
Publication date:
2000-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:90cf2270-ad17-486c-89fe-d94b3de0ce69
Source identifiers:
26882
Local pid:
pubs:26882

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