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Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.

Abstract:

One of the most common human autoimmune diseases, alopecia areata (AA), is characterized by sudden, often persisting and psychologically devastating hair loss. Animal models have helped greatly to elucidate critical cellular and molecular immune pathways in AA. The two most prominent ones are inbred C3H/HeJ mice which develop an AA-like hair phenotype spontaneously or after experimental induction, and healthy human scalp skin xenotransplanted onto SCID mice, in which a phenocopy of human AA i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Publisher:
Elsevier B.V. Publisher's website
Journal:
Autoimmunity reviews Journal website
Volume:
15
Issue:
7
Pages:
726-735
Publication date:
2016-03-10
Acceptance date:
2016-03-02
DOI:
EISSN:
1873-0183
ISSN:
1568-9972
URN:
uuid:90cd68ce-70ec-47fe-9d12-fc54a8968d9b
Source identifiers:
611649
Local pid:
pubs:611649
Paper number:
7

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