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Journal article

Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue.

Abstract:

Protein sulfenic acids are reactive intermediates in the catalytic cycles of many enzymes as well as the in formation of other redox states. Sulfenic acid formation is a reversible post-translational modification with potential for protein regulation. Dimedone (5,5-dimethyl-1,3-cyclohexanedione) is commonly used in vitro to study sulfenation of purified proteins, selectively "tagging" them, allowing monitoring by mass spectrometry. However dimedone is of little use in complex protein mixtures...

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Publication status:
Published

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Publisher copy:
10.1074/mcp.m700065-mcp200

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Journal:
Molecular and cellular proteomics : MCP
Volume:
6
Issue:
9
Pages:
1473-1484
Publication date:
2007-09-05
DOI:
EISSN:
1535-9484
ISSN:
1535-9476
URN:
uuid:90c0141b-7a99-4178-b32d-feee2f984518
Source identifiers:
229150
Local pid:
pubs:229150

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