Journal article icon

Journal article

Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection.

Abstract:

Persistent viral infections induce the differentiation and accumulation of large numbers of senescent CD8(+) T cells, raising the possibility that repetitive stimulation drives clones of T cells to senesce. It is therefore unclear whether T cell responses are maintained by the self-renewal of Ag-experienced peripheral T cell subsets or by the continuous recruitment of newly generated naive T cells during chronic infections. Using a transgenic mouse model that permits the indelible marking of ...

Expand abstract

Actions


Access Document


Publisher copy:
10.4049/jimmunol.1002537

Authors


Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
185
Issue:
12
Pages:
7141-7145
Publication date:
2010-12-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:90b99c91-602c-4547-a0e0-99e61bf899eb
Source identifiers:
491246
Local pid:
pubs:491246

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP