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Journal article

Replication factories.

Abstract:

During S phase, DNA replication begins at numerous sites throughout the genome. Textbooks would have us believe that each replication fork tracks along the immobile DNA until it runs into the adjacent fork, but recent results question this view. Various studies show that replication forks are concentrated in immobile 'factory' units throughout the nucleus. Each factory contains as many as 40 different replication forks and associated polymerases. These findings suggest that newly synthesized ...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Trends in cell biology More from this journal
Volume:
4
Issue:
2
Pages:
48-52
Publication date:
1994-02-01
DOI:
EISSN:
1879-3088
ISSN:
0962-8924
Language:
English
Pubs id:
pubs:22641
UUID:
uuid:90ae62e9-fb04-47cb-a63f-94102cee20c3
Local pid:
pubs:22641
Source identifiers:
22641
Deposit date:
2012-12-19

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