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Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.

Abstract:

AIMS: Impaired energy metabolism has been implicated in the pathogenesis of heart failure. Hyperpolarized (13)C magnetic resonance (MR), in which (13)C-labelled metabolites are followed using MR imaging (MRI) or spectroscopy (MRS), has enabled non-invasive assessment of pyruvate metabolism. We investigated the hypothesis that if we serially examined a model of heart failure using non-invasive hyperpolarized [(13)C]pyruvate with MR, the profile of in vivo pyruvate oxidation would change throug...

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Publication status:
Published

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Publisher copy:
10.1093/eurjhf/hfs192

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Journal:
European journal of heart failure More from this journal
Volume:
15
Issue:
2
Pages:
130-140
Publication date:
2013-02-01
DOI:
EISSN:
1879-0844
ISSN:
1388-9842

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