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Journal article

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human.

Abstract:

Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activation and, if defective, is associated with autoimmune disease, yet its impact on specific B cell tolerance checkpoints is unknown. Here we show that reduced expression of FcγRIIb enhances the deletion and anergy of autoreactive immature B cells, but in contrast promotes autoreactive B cel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-09434-0

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Department:
Unknown
Role:
Author
ORCID:
0000-0002-6838-0711
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Name:
Wellcome Trust
Grant:
083650/Z/07/Z
Publisher:
Nature Research
Journal:
Nature Communications More from this journal
Volume:
10
Article number:
1970
Publication date:
2019-04-23
Acceptance date:
2019-02-21
DOI:
EISSN:
2041-1723
Pmid:
31036800
Language:
English
Keywords:
Pubs id:
pubs:995926
UUID:
uuid:9090860a-d129-4e9e-80d2-22efd980fc80
Local pid:
pubs:995926
Source identifiers:
995926
Deposit date:
2019-05-06

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