- Abstract:
-
Meiosis involves two successive rounds of chromosome segregation without an intervening S phase. Exit from meiosis I is distinct from mitotic exit, in that replication origins are not licensed by Mcm2-7 chromatin binding, but spindle disassembly occurs during a transient interphase-like state before meiosis II. The absence of licensing is assumed to explain the block to DNA replication, but this has not been formally tested. Here we attempt to subvert this block by expressing the licensing co...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1091/mbc.e12-11-0825
-
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- Journal:
- Molecular biology of the cell
- Volume:
- 24
- Issue:
- 5
- Pages:
- 578-587
- Publication date:
- 2013-03-05
- DOI:
- EISSN:
-
1939-4586
- ISSN:
-
1059-1524
- URN:
-
uuid:9088aeaa-0724-4543-a544-643ebee0d7ab
- Source identifiers:
-
374295
- Local pid:
- pubs:374295
- Copyright date:
- 2013
Journal article
Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.
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