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Journal article

Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.

Abstract:

Meiosis involves two successive rounds of chromosome segregation without an intervening S phase. Exit from meiosis I is distinct from mitotic exit, in that replication origins are not licensed by Mcm2-7 chromatin binding, but spindle disassembly occurs during a transient interphase-like state before meiosis II. The absence of licensing is assumed to explain the block to DNA replication, but this has not been formally tested. Here we attempt to subvert this block by expressing the licensing co...

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Publication status:
Published

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Publisher copy:
10.1091/mbc.e12-11-0825

Authors


Méchali, M More by this author
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Journal:
Molecular biology of the cell
Volume:
24
Issue:
5
Pages:
578-587
Publication date:
2013-03-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:9088aeaa-0724-4543-a544-643ebee0d7ab
Source identifiers:
374295
Local pid:
pubs:374295

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