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Heritability and genetic variance of dementia with Lewy bodies

Abstract:

Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established that a substantial portion of the genetic heritable component of complex traits is not captured by genome-wide significant SNPs. To overcome this issue, we have estimated the proportion of phenotypic variance explained by genetic variability (SNP ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.nbd.2019.04.004

Authors


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Role:
Author
ORCID:
0000-0003-1784-5483
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Name:
Medical Research Council
Grant:
MR/L022656/1
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Name:
Michael J Fox Foundation for Parkinson's Research
Grant:
10080
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Name:
National Institute on Aging
Grant:
P01 AG004953
Publisher:
Elsevier
Journal:
Neurobiology of Disease More from this journal
Volume:
127
Pages:
492-501
Publication date:
2019-04-03
Acceptance date:
2019-04-02
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
Pmid:
30953760
Language:
English
Keywords:
Pubs id:
990958
Local pid:
pubs:990958
Deposit date:
2020-03-13

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