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Activation of endocytosis as an adaptation to the mammalian host by trypanosomes.

Abstract:

Immune evasion in African trypanosomes is principally mediated by antigenic variation, but rapid internalization of surface-bound immune factors may contribute to survival. Endocytosis is upregulated approximately 10-fold in bloodstream compared to procyclic forms, and surface coat remodeling accompanies transition between these life stages. Here we examined expression of endocytosis markers in tsetse fly stages in vivo and monitored modulation during transition from bloodstream to procyclic ...

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Publisher copy:
10.1128/ec.00213-07

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Peacock, L More by this author
Matthews, K More by this author
Journal:
Eukaryotic cell
Volume:
6
Issue:
11
Pages:
2029-2037
Publication date:
2007-11-05
DOI:
EISSN:
1535-9786
ISSN:
1535-9778
URN:
uuid:907ba2d3-c650-449c-8cdb-81f40bd5843f
Source identifiers:
56263
Local pid:
pubs:56263

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