Journal article icon

Journal article

Fragment screening of cyclin G-associated kinase by weak affinity chromatography.

Abstract:

Fragment-based drug discovery (FBDD) has become a new strategy for drug discovery where lead compounds are evolved from small molecules. These fragments form low affinity interactions (dissociation constant (K(D)) = mM - μM) with protein targets, which require fragment screening methods of sufficient sensitivity. Weak affinity chromatography (WAC) is a promising new technology for fragment screening based on selective retention of fragments by a drug target. Kinases are a major pharmaceutical...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00216-012-6335-6

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
Journal:
Analytical and bioanalytical chemistry
Volume:
404
Issue:
8
Pages:
2417-2425
Publication date:
2012-11-05
DOI:
EISSN:
1618-2650
ISSN:
1618-2642
URN:
uuid:907b9e66-f707-4276-b873-f7e979e5d260
Source identifiers:
366415
Local pid:
pubs:366415

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP