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Journal article

Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

Abstract:

Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular events controlling this regenerative capacity, however, are unknown. We found that two distinct states of virus-specific CD8(+) T cells exist in chronically infected mice and humans. Differential expression of the T-box transcription factors T-bet and Eomesodermin (Eomes) facilitated the cooperative maintenance of the pool of antiviral...

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Publication status:
Published

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Publisher copy:
10.1126/science.1229620

Authors


Publisher:
American Association for the Advancement of Science
Journal:
Science (New York, N.Y.) More from this journal
Volume:
338
Issue:
6111
Pages:
1220-1225
Publication date:
2012-11-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Language:
English
Keywords:
Pubs id:
pubs:365449
UUID:
uuid:9075663f-cef2-4250-85ad-f45ab31e5610
Local pid:
pubs:365449
Source identifiers:
365449
Deposit date:
2013-11-16

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