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Journal article

Sp1 functions in a chromatin-dependent manner to augment human alpha-globin promoter activity.

Abstract:

The 5' flanking region of the human alpha-globin gene is highly G + C rich and contains multiple copies of the consensus sequence for the Sp1 binding site. We investigated the role of this G + C-rich region in augmenting alpha-globin promoter activity in the presence of the far-upstream alpha-globin enhancer, HS-40. We show that in transiently transfected erythroid cells, deletion of the alpha-globin G + C-rich 5' flanking region has no effect on alpha-globin promoter activity. However, upon ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.92.16.7237

Authors


Pondel, MD More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Pearson, L More by this author
Craddock, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
92
Issue:
16
Pages:
7237-7241
Publication date:
1995-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:9072de61-367c-4f7d-9410-6cbb93e6d212
Source identifiers:
20669
Local pid:
pubs:20669

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