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Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia.

Abstract:

BACKGROUND: Partial liquid ventilation with perfluorocarbon is a new therapeutic strategy to treat various lung disorders. The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. METHODS: Male Wistar rats (weight, 275-300 g; n, 75) were infected via direct intratracheal inoculation with ca 10(9) colony-forming units of viable Streptococcus pneumoniae, serotype 3, and 24 h after ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
Anesthesiology
Volume:
88
Issue:
1
Pages:
218-223
Publication date:
1998-01-05
DOI:
EISSN:
1528-1175
ISSN:
0003-3022
URN:
uuid:906dcebd-b0bd-4f18-bffd-e511057dd4ed
Source identifiers:
384058
Local pid:
pubs:384058

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