Journal article icon

Journal article

Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina.

Abstract:

BACKGROUND: The cell-cycle regulator Cyclin D1 is expressed in embryonic retinal progenitor cells (RPCs) and regulates their cell-cycle rate and neurogenic output. We report here that Cyclin D1 also has important functions in postnatal retinal histogenesis. RESULTS: The initial production of Müller glia and bipolar cells was enhanced in Cyclin D1 knockout (Ccnd1(-/-) ) retinas. Despite a steeper than normal rate of depletion of the RPC population at embryonic ages, postnatal Ccnd1(-/-) retina...

Expand abstract

Actions


Access Document


Publisher copy:
10.1002/dvdy.23782

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Developmental dynamics : an official publication of the American Association of Anatomists More from this journal
Volume:
241
Issue:
5
Pages:
941-952
Publication date:
2012-05-01
DOI:
EISSN:
1097-0177
ISSN:
1058-8388
Language:
English
Keywords:
Pubs id:
pubs:430743
UUID:
uuid:906d6aaa-8caf-41d6-83c5-8c9d9e65f2a6
Local pid:
pubs:430743
Source identifiers:
430743
Deposit date:
2014-05-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP