Journal article icon

Journal article

Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion.

Abstract:

Acetylcholine (ACh) is a known modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic ACh receptors (nAChRs). Yet, the subunit composition and specific location of nAChRs involved in DA-mediated locomotion remain to be established in vivo. Mice lacking the beta2 subunit of nAChRs (beta2KO) display striking hyperactivity in the open field, which suggests an imbalance in DA neurotransmission. Here, we performed the selective gene rescue of functional be...

Expand abstract

Actions


Access Document


Publisher copy:
10.1073/pnas.0807635105

Authors


Robledo, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
41
Pages:
15991-15996
Publication date:
2008-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:906c8b2f-a0ad-46fe-be43-83b1dae1a415
Source identifiers:
426705
Local pid:
pubs:426705

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP