Journal article
Within-host evolution of bacterial pathogens
- Abstract:
- Whole-genome sequencing has opened the way for investigating the dynamics and genomic evolution of bacterial pathogens during the colonization and infection of humans. The application of this technology to the longitudinal study of adaptation in an infected host — in particular, the evolution of drug resistance and host adaptation in patients who are chronically infected with opportunistic pathogens — has revealed remarkable patterns of convergent evolution, suggestive of an inherent repeatability of evolution. In this Review, we describe how these studies have advanced our understanding of the mechanisms and principles of within-host genome evolution, and we consider the consequences of findings such as a potent adaptive potential for pathogenicity. Finally, we discuss the possibility that genomics may be used in the future to predict the clinical progression of bacterial infections and to suggest the best option for treatment.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 1.6MB, Terms of use)
-
- Publisher copy:
- 10.1038/nrmicro.2015.13
Authors
+ Royal Society
More from this funder
- Funding agency for:
- Wilson, DJ
- Grant:
- Sir Henry Dale Fellow 101237/Z/13/Z
+ Wellcome Trust
More from this funder
- Funding agency for:
- Wilson, DJ
- Grant:
- Sir Henry Dale Fellow 101237/Z/13/Z
- WT098615
+ National Institute for Health Research
More from this funder
- Funding agency for:
- Peto, TE
- Crook, DW
- Grant:
- HPRU-2012-10041
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Reviews Microbiology More from this journal
- Volume:
- 14
- Issue:
- 3
- Pages:
- 150–162
- Publication date:
- 2016-01-19
- DOI:
- EISSN:
-
1740-1534
- ISSN:
-
1740-1526
- Language:
-
English
- Pubs id:
-
pubs:598010
- UUID:
-
uuid:905a2ae3-d556-47c2-b6d2-91dae4ecf488
- Local pid:
-
pubs:598010
- Source identifiers:
-
598010
- Deposit date:
-
2016-02-04
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2016
- Rights statement:
- © 2016 Macmillan Publishers Limited. All rights reserved
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at https://dx.doi.org/10.1038/nrmicro.2015.13
If you are the owner of this record, you can report an update to it here: Report update to this record