Haemoglobin E beta thalassaemia in Sri Lanka.

Journal article

Haemoglobin E beta thalassaemia is the commonest form of severe thalassaemia in many Asian countries, but little is known about its natural history, the reasons for clinical diversity, or its management. We studied 109 Sri Lankan patients with the disorder over 5 years. 25 patients were not receiving transfusion; transfusion was stopped with no deleterious effect in a further 37. We identified several genetic and environmental factors that might contribute to the phenotypic diversity of the d...

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Authors: Premawardhena, A; Fisher, C; Olivieri, N; de Silva, S; Arambepola, M

• Publication status: Published
• Journal: Lancet (London, England)
• Volume: 366
• Issue: 9495
• Pages: 1467-1470
• Publication date: 2005-10-01
• DOI: 10.1016/S0140-6736(05)67396-5
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Child, Preschool; Sri Lanka; Adult; Middle Aged; Female; Male; beta-Thalassemia; Splenectomy; Blood Transfusion; Child; Infant; Adolescent; Humans; Hemoglobin E