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Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques

Abstract:

Stable isotopes are ideal labels for studying biological processes because they have little or no effect on the biochemical properties of target molecules. The NanoSIMS is a tool that can image the distribution of stable isotope labels with up to 50. nm spatial resolution and with good quantitation. This combination of features has enabled several groups to undertake significant experiments on biological problems in the last decade. Combining the NanoSIMS with other imaging techniques also en...

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Publisher copy:
10.1016/j.ymeth.2014.02.012

Authors


Goulbourne, CN More by this author
Rakowska, PD More by this author
Hughes, GM More by this author
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Publisher:
Academic Press Inc.
Journal:
Methods
Volume:
68
Issue:
2
Pages:
317-324
Publication date:
2014-07-01
DOI:
EISSN:
1095-9130
ISSN:
1046-2023
URN:
uuid:9040d1e5-b041-45c5-a1c0-f6c603908f5a
Source identifiers:
470926
Local pid:
pubs:470926

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