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NMDA spikes enhance action potential generation during sensory input

Abstract:

Recent evidence in vitro suggests that the tuft dendrites of pyramidal neurons are capable of evoking local NMDA receptor-dependent electrogenesis, so-called NMDA spikes. However, it has so far proved difficult to demonstrate their existence in vivo. Moreover, it is not clear whether NMDA spikes are relevant to the output of pyramidal neurons. We found that local NMDA spikes occurred in tuft dendrites of layer 2/3 pyramidal neurons both spontaneously and following sensory input, and had a lar...

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Publisher copy:
10.1038/nn.3646

Authors


Palmer, LM More by this author
Larkum, ME More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Nature Neuroscience
Volume:
17
Issue:
3
Pages:
383-390
Publication date:
2014-03-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:903f68c8-242e-4915-84f5-6450791d4e9d
Source identifiers:
452522
Local pid:
pubs:452522

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