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Proinflammatory cytokine (TNFalpha/IL-1alpha) induction of human osteoclast formation.

Abstract:

TNFalpha and IL-1alpha are potent stimulators of bone resorption in vivo and in vitro. Recently, it has been demonstrated that these two cytokines directly induce osteoclastogenesis in mouse marrow cultures. This study determined whether TNFalpha (+/- IL-1alpha) is also capable of inducing human osteoclastogenesis. The CD14(+) monocyte fraction of human peripheral mononuclear cells was cultured with TNFalpha +/- IL-1alpha in the presence of M-CSF. TNFalpha induced the formation of multinuclea...

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Publication status:
Published

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Publisher copy:
10.1002/path.1190

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of pathology More from this journal
Volume:
198
Issue:
2
Pages:
220-227
Publication date:
2002-10-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417

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