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Quantitative study of the effect of tissue microstructure on contraction in a computational model of rat left ventricle

Abstract:

Tissue microstructure, in particular the alignment of myocytes (fibre direction) and their lateral organisation into sheets, is fundamental to cardiac function. We studied the effect of microstructure on contraction in a computational model of rat left ventricular electromechanics. Different fibre models, globally rule-based or locally optimised to DT-MRI data, were compared, in order to understand whether a subject-specific fibre model would enhance the predi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0092792

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Role:
Author
ORCID:
0000-0001-9750-9425
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Role:
Author
ORCID:
0000-0002-0856-544X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Oxford college:
St Catherines College
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
9
Issue:
4
Pages:
e92792
Publication date:
2014-04-02
Acceptance date:
2014-02-26
DOI:
EISSN:
1932-6203
Pubs id:
pubs:458678
URN:
uri:90311d6b-88ce-4bd8-b562-c1f2536847e0
UUID:
uuid:90311d6b-88ce-4bd8-b562-c1f2536847e0
Local pid:
pubs:458678
Paper number:
ARTN e92792
Language:
English
Keywords:

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