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Using an integrated -omics approach to identify key cellular processes that are disturbed in the kidney following brain death.

Abstract:

In an era where we are becoming more reliant on vulnerable kidneys for transplantation from older donors, there is an urgent need to understand how brain death leads to kidney dysfunction and, hence, how this can be prevented. Using a rodent model of hemorrhagic stroke and next-generation proteomic and metabolomic technologies, we aimed to delineate which key cellular processes are perturbed in the kidney after brain death. Pathway analysis of the proteomic signature of kidneys from brain-dea...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1111/ajt.13626

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Cellular and Molecular Physiology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Target Discovery Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Target Discovery Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Cellular and Molecular Physiology
Robolledo, R More by this author
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Medical Research Council More from this funder
Royal College of Surgeons More from this funder
Publisher:
Wiley Publisher's website
Journal:
American Journal of Transplantation Journal website
Volume:
16
Issue:
5
Pages:
1421–1440
Publication date:
2016-03-10
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:902b76a9-23cb-4dc1-90f9-e3af7ec56054
Source identifiers:
586277
Local pid:
pubs:586277
Language:
English

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