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Journal article

Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage

Abstract:

Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenesis. They emerge from a specialized endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dorsal aorta (DA). In Xenopus, we have been studying the gene regulatory networks (GRNs) required for the formation of HSCs, and critically found that the hemogenic potential is defined at an earlier time point when precursors to the DA express hematopoietic as well ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1610615114

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Institute of Molecular Medicine
Role:
Author
ORCID:
0000-0002-1568-8165
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Name:
Medical Research Council
Grant:
MC_UU_12009/8
Publisher:
Proceedings of the National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
114
Issue:
23
Pages:
5814-5821
Publication date:
2017-06-06
Acceptance date:
2017-02-06
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
28584091
Language:
English
Keywords:
Pubs id:
pubs:700120
UUID:
uuid:90185974-db68-42dc-8c7d-f9f8170d1b77
Local pid:
pubs:700120
Source identifiers:
700120
Deposit date:
2019-02-13

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