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Pan-genomic binding of hypoxia-inducible transcription factors.

Abstract:

Hypoxia-inducible transcription factors (HIFs) mediate the cellular response to hypoxia. HIF-DNA binding triggers a transcriptional program that acts to both restore oxygen homeostasis and adapt cells to low oxygen availability. In this context, HIF is centrally involved in many physiologic and pathophysiological processes such as development, high altitude adaptation, ischemic disease, inflammation, and cancer. The recent development of chromatin immunoprecipitation coupled to genome-wide DN...

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Publication status:
Published

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Publisher copy:
10.1515/hsz-2012-0351

Authors


Schödel, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Journal:
Biological chemistry
Volume:
394
Issue:
4
Pages:
507-517
Publication date:
2013-04-05
DOI:
EISSN:
1437-4315
ISSN:
1431-6730
URN:
uuid:9012dc4e-0dbd-4056-a659-29830908532d
Source identifiers:
395591
Local pid:
pubs:395591

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