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Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats.

Abstract:

Proteasome inhibitors are novel therapeutic agents for the treatment of cancer and other severe disorders. One of the possible side effects is influencing the metabolism of proteins. The aim of our study was to evaluate the influence of three proteasome inhibitors MG132, ZL(3)VS and AdaAhx(3)L(3)VS on protein metabolism and leucine oxidation in incubated skeletal muscle of control and septic rats. Total proteolysis was determined according to the rates of tyrosine release into the medium duri...

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Publication status:
Published

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Authors


Kadlcíková, J More by this author
Holecek, M More by this author
Safránek, R More by this author
Kessler, BM More by this author
Journal:
International journal of experimental pathology
Volume:
85
Issue:
6
Pages:
365-371
Publication date:
2004-12-05
DOI:
EISSN:
1365-2613
ISSN:
0959-9673
URN:
uuid:9011eb82-73ea-4649-a35d-2557601a9ff2
Source identifiers:
21155
Local pid:
pubs:21155

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