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Structural comparison of human mammalian ste20-like kinases.

Abstract:

BACKGROUND: The serine/threonine mammalian Ste-20 like kinases (MSTs) are key regulators of apoptosis, cellular proliferation as well as polarization. Deregulation of MSTs has been associated with disease progression in prostate and colorectal cancer. The four human MSTs are regulated differently by C-terminal regions flanking the catalytic domains. PRINCIPAL FINDINGS: We have determined the crystal structure of kinase domain of MST4 in complex with an ATP-mimetic inhibitor. This is the firs...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0011905

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
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Structural Genomics Consortium More from this funder
Oxford University Nuffield Department of Medicine More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
8
Pages:
Article: e11905
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:90109de9-37b7-49e1-ac92-514b01f5df5c
Source identifiers:
67483
Local pid:
pubs:67483

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