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2'-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

Abstract:

Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible approach to the synthesis of double spin-labeled DNA duplexes, where 2′-alkynylnucleosides are incorporated at terminal and internal positions on complementary strands. Post-DNA synthesis copper-catalyzed azide–alkyne cycloaddition (CuAAC) reactions with a variety of s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1021/jacs.6b05421

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
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Funding agency for:
Lovett, JE
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Publication date:
2016-07-13
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Source identifiers:
634545
Local pid:
pubs:634545

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