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Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2).

Abstract:

BACKGROUND: Randomized clinical trials (RCTs) stopped early for benefit often receive great attention and affect clinical practice, but pose interpretational challenges for clinicians, researchers, and policy makers. Because the decision to stop the trial may arise from catching the treatment effect at a random high, truncated RCTs (tRCTs) may overestimate the true treatment effect. The Study Of Trial Policy Of Interim Truncation (STOPIT-1), which systematically reviewed the epidemiology and ...

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Publication status:
Published

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Publisher copy:
10.1186/1745-6215-10-49

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Journal:
Trials More from this journal
Volume:
10
Issue:
1
Pages:
49
Publication date:
2009-01-01
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
Language:
English
Keywords:
Pubs id:
pubs:116567
UUID:
uuid:8ffaba40-4f30-4791-a559-56dbd5a8a489
Local pid:
pubs:116567
Source identifiers:
116567
Deposit date:
2012-12-19

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