Journal article icon

Journal article

Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites.

Abstract:

Both the sequence of a promoter and the position of a gene in 3D nuclear space play crucial roles in gene regulation, but few studies address their inter-relationship. Using human and viral promoters on mini-chromosomes and RNA fluorescence in situ hybridization coupled to 'high-precision' localization, we show that promoters binding the same transcription factors and responding to the same signaling pathways tend to be co-transcribed in the same transcription factories. We go on to suggest h...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1242/jcs.123653

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
126
Issue:
Pt 9
Pages:
2052-2059
Publication date:
2013-05-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:8fc9744e-19c8-40d8-ad95-de8f3b60d8fe
Source identifiers:
387117
Local pid:
pubs:387117

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP