- Abstract:
-
Both the sequence of a promoter and the position of a gene in 3D nuclear space play crucial roles in gene regulation, but few studies address their inter-relationship. Using human and viral promoters on mini-chromosomes and RNA fluorescence in situ hybridization coupled to 'high-precision' localization, we show that promoters binding the same transcription factors and responding to the same signaling pathways tend to be co-transcribed in the same transcription factories. We go on to suggest h...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/jcs.123653
-
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- Journal:
- Journal of cell science
- Volume:
- 126
- Issue:
- Pt 9
- Pages:
- 2052-2059
- Publication date:
- 2013-05-05
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- URN:
-
uuid:8fc9744e-19c8-40d8-ad95-de8f3b60d8fe
- Source identifiers:
-
387117
- Local pid:
- pubs:387117
- Copyright date:
- 2013
Journal article
Promoter type influences transcriptional topography by targeting genes to distinct nucleoplasmic sites.
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