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Dimer initiation signal of human immunodeficiency virus type 1: its role in partner selection during RNA copackaging and its effects on recombination.

Abstract:

Frequent human immunodeficiency virus type 1 (HIV-1) recombination occurs during DNA synthesis when portions of the two copackaged RNAs are used as templates to generate a hybrid DNA copy. Therefore, the frequency of copackaging of genomic RNAs from two different viruses (heterozygous virion formation) affects the generation of genotypically different recombinants. We hypothesized that the selection of copackaged RNA partners is largely determined by Watson-Crick pairing at the dimer initiati...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02589-06

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of virology More from this journal
Volume:
81
Issue:
8
Pages:
4002-4011
Publication date:
2007-04-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:228592
UUID:
uuid:8fc81a71-0857-48b1-ae33-f72474febadf
Local pid:
pubs:228592
Source identifiers:
228592
Deposit date:
2012-12-19

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