In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging.

Akhtar, AM; Schneider, JE; Chapman, SJ; Jefferson, A; Digby, JE; Mankia, K; Chen, Y; McAteer, MA; Wood, KJ; Choudhury, RP

Abstract:

Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. We hypothesized that microparticles of iron oxide targeting VCAM-1 (VCAM-MPIO) would depict "ischemic memory" and enable in vivo assessment of VCAM-1 expression. Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg body weight). Contrast agent bound rapidly (<30 minu...

Expand abstract

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Akhtar, A. M., Schneider, J. E., Chapman, S. J., Jefferson, A., Digby, J. E., Mankia, K., Chen, Y., McAteer, M. A., Wood, K. J., & Choudhury, R. P. (2010). In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging. PloS One, 5(9).

MLA Style

Akhtar, A. M., et al. “In Vivo Quantification of VCAM-1 Expression in Renal Ischemia Reperfusion Injury Using Non-Invasive Magnetic Resonance Molecular Imaging.” PloS One, vol. 5, no. 9, PloS one, 2010.

Chicago Style

Akhtar, AM, JE Schneider, SJ Chapman, A Jefferson, JE Digby, K Mankia, Y Chen, MA McAteer, KJ Wood, and RP Choudhury. 2010. “In Vivo Quantification of VCAM-1 Expression in Renal Ischemia Reperfusion Injury Using Non-Invasive Magnetic Resonance Molecular Imaging.” PloS One 5 (9).
Tweet
Print

Authors

Akhtar, AM More by this author

Schneider, JE More by this author

Chapman, SJ More by this author

Jefferson, A More by this author

Digby, JE More by this author

Expand authors...

Bibliographic Details

Journal:: PloS one
Volume:: 5
Issue:: 9
Publication date:: 2010
EISSN:: 1932-6203
URN:: uuid:8fc31aa3-e491-4cfb-90c8-2e52f837b90d
Source identifiers:: 127420
Local pid:: pubs:127420

Terms of use

License:: Terms and Conditions of Use for Oxford University Research Archive

Views & Downloads

Metrics

If you are the owner of this record, you can report an update to it here: Report update to this record