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In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging.

Abstract:

Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. We hypothesized that microparticles of iron oxide targeting VCAM-1 (VCAM-MPIO) would depict "ischemic memory" and enable in vivo assessment of VCAM-1 expression. Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg body weight). Contrast agent bound rapidly (<30 minu...

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Authors


Akhtar, AM More by this author
Schneider, JE More by this author
Chapman, SJ More by this author
Jefferson, A More by this author
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Journal:
PloS one
Volume:
5
Issue:
9
Publication date:
2010
EISSN:
1932-6203
URN:
uuid:8fc31aa3-e491-4cfb-90c8-2e52f837b90d
Source identifiers:
127420
Local pid:
pubs:127420

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