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Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N(ε)-trimethyllysine

Abstract:
N(ε)-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N(ε)-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N(ε)-trimethyllysine.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/c6cc08381a

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Chemical Communication Journal website
Volume:
53
Issue:
2
Pages:
440-442
Publication date:
2016-12-14
Acceptance date:
2016-11-29
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
Pubs id:
pubs:666478
URN:
uri:8fbd5c2c-4946-464d-a273-9a2a03fdf8e3
UUID:
uuid:8fbd5c2c-4946-464d-a273-9a2a03fdf8e3
Local pid:
pubs:666478
Language:
English
Keywords:

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