- Abstract:
-
During tumour progression, oxygen tension in the microenvironment surrounding tumour cells is reduced, resulting in hypoxia. It is well established that cancer cells resist the negative effects of hypoxia by inducing angiogenesis predominantly via the activity of transcription factor hypoxia-inducible factor-1 (HIF-1). However, more recently HIF-1α has also been linked to increased invasive potential, although the molecular mechanisms remain to be defined. Invasive cancer cells are thought to...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 985.9KB)
-
- Publisher copy:
- 10.1098/rsob.120159
-
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- Publisher:
- Royal Society Publisher's website
- Journal:
- Open Biology Journal website
- Volume:
- 3
- Issue:
- 6
- Pages:
- 120159
- Chapter number:
- ARTN 120159
- Publication date:
- 2013-06-05
- DOI:
- EISSN:
-
2046-2441
- ISSN:
-
2046-2441
- URN:
-
uuid:8fbbe653-5c97-4c2a-a379-772852cd3700
- Source identifiers:
-
401224
- Local pid:
- pubs:401224
- Copyright holder:
- Md Hashim et al.
- Copyright date:
- 2013
- Notes:
- © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License, which permits unrestricted use, provided the original author and source are credited. This is the publisher's version of the article. The final version is available online from the Royal Society at: [10.1098/rsob.120159]
Journal article
Hypoxia-induced invadopodia formation: a role for β-PIX.
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