Journal article icon

Journal article

Hypoxia-induced invadopodia formation: a role for β-PIX.

Abstract:

During tumour progression, oxygen tension in the microenvironment surrounding tumour cells is reduced, resulting in hypoxia. It is well established that cancer cells resist the negative effects of hypoxia by inducing angiogenesis predominantly via the activity of transcription factor hypoxia-inducible factor-1 (HIF-1). However, more recently HIF-1α has also been linked to increased invasive potential, although the molecular mechanisms remain to be defined. Invasive cancer cells are thought to...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1098/rsob.120159

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
Expand authors...
Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
3
Issue:
6
Pages:
120159
Chapter number:
ARTN 120159
Publication date:
2013-06-05
DOI:
EISSN:
2046-2441
ISSN:
2046-2441
URN:
uuid:8fbbe653-5c97-4c2a-a379-772852cd3700
Source identifiers:
401224
Local pid:
pubs:401224

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP