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Journal article

Hypoxia-induced invadopodia formation: a role for β-PIX.

Abstract:

During tumour progression, oxygen tension in the microenvironment surrounding tumour cells is reduced, resulting in hypoxia. It is well established that cancer cells resist the negative effects of hypoxia by inducing angiogenesis predominantly via the activity of transcription factor hypoxia-inducible factor-1 (HIF-1). However, more recently HIF-1α has also been linked to increased invasive potential, although the molecular mechanisms remain to be defined. Invasive cancer cells are thought to...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsob.120159

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
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Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
3
Issue:
6
Pages:
120159
Publication date:
2013-06-01
DOI:
EISSN:
2046-2441
ISSN:
2046-2441
Source identifiers:
401224
Language:
English
Keywords:
Pubs id:
pubs:401224
UUID:
uuid:8fbbe653-5c97-4c2a-a379-772852cd3700
Local pid:
pubs:401224
Deposit date:
2013-11-16

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