Journal article
Hypoxia-induced invadopodia formation: a role for β-PIX.
- Abstract:
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During tumour progression, oxygen tension in the microenvironment surrounding tumour cells is reduced, resulting in hypoxia. It is well established that cancer cells resist the negative effects of hypoxia by inducing angiogenesis predominantly via the activity of transcription factor hypoxia-inducible factor-1 (HIF-1). However, more recently HIF-1α has also been linked to increased invasive potential, although the molecular mechanisms remain to be defined. Invasive cancer cells are thought to...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 985.9KB)
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- Publisher copy:
- 10.1098/rsob.120159
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Authors
Bibliographic Details
- Publisher:
- Royal Society Publisher's website
- Journal:
- Open Biology Journal website
- Volume:
- 3
- Issue:
- 6
- Pages:
- 120159
- Publication date:
- 2013-06-01
- DOI:
- EISSN:
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2046-2441
- ISSN:
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2046-2441
- Source identifiers:
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401224
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:401224
- UUID:
-
uuid:8fbbe653-5c97-4c2a-a379-772852cd3700
- Local pid:
- pubs:401224
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Md Hashim et al
- Copyright date:
- 2013
- Notes:
- © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License, which permits unrestricted use, provided the original author and source are credited. This is the publisher's version of the article. The final version is available online from the Royal Society at: [10.1098/rsob.120159]
- Licence:
- CC Attribution (CC BY)
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