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-(S)-Alpha-phenyl-2-pyridine-ethanamine Dihydrochloride-, a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia.

Abstract:

[(S)-Alpha-phenyl-2-pyridine-ethanamine dihydrochloride] (ARL 15896AR) is a low affinity uncompetitive N-methyl-D-aspartic acid receptor antagonist that was tested in animal models of anoxia and ischemia. Pretreatment of rodents with ARL 15896AR extended survival time during exposure to hypoxia. With the rat four-vessel occlusion model of global ischemia (20 min), oral dosing commencing at reflow, resulted in significant protection of the CA1 hippocampal neurons. ARL 15896AR was, however, ine...

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Publication status:
Published

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Authors


Cregan, EF More by this author
Peeling, J More by this author
Corbett, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Saunders, J More by this author
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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
283
Issue:
3
Pages:
1412-1424
Publication date:
1997-12-05
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:8fba8a08-1088-4363-aff5-5418687e48f8
Source identifiers:
79351
Local pid:
pubs:79351

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