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Genetically encoded proton sensors reveal activity-dependent pH changes in neurons.

Abstract:

The regulation of hydrogen ion concentration (pH) is fundamental to cell viability, metabolism, and enzymatic function. Within the nervous system, the control of pH is also involved in diverse and dynamic processes including development, synaptic transmission, and the control of network excitability. As pH affects neuronal activity, and can also itself be altered by neuronal activity, the existence of tools to accurately measure hydrogen ion fluctuations is important for understanding the rol...

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Publisher copy:
10.3389/fnmol.2012.00068

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Frontiers in molecular neuroscience More from this journal
Volume:
5
Issue:
MAY 2012
Pages:
68
Publication date:
2012-01-01
DOI:
EISSN:
1662-5099
ISSN:
1662-5099
Language:
English
Keywords:
Pubs id:
pubs:334795
UUID:
uuid:8fae8122-149a-4953-83d3-2b8b76b9eab8
Local pid:
pubs:334795
Source identifiers:
334795
Deposit date:
2012-12-19

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