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Journal article

Short-sighted virus evolution and a germline hypothesis for chronic viral infections

Abstract:

With extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to changing environments. This ability is generally beneficial to viruses as it allows them to evade host immune responses, evolve new behaviours and exploit ecological niches. However, natural selection typically generates adaptation in response to the immediate selection pressures that a virus experiences in its current host. Consequently, we argue that some viruses, particularly those chara...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Oxford college:
Linacre College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More from this funder
Name:
Seventh Framework Programme
Funding agency for:
Pybus, O
Grant:
614725-PATHPHYLODYN
More from this funder
Name:
Wellcome Trust
Grant:
107653/Z/15/Z
wtvm055984
Funding agency for:
Lythgoe, K
More from this funder
Name:
Royal Society
Funding agency for:
Lythgoe, K
Grant:
wtvm055984
107653/Z/15/Z
More from this funder
Name:
Natural Environment Research Council
Grant:
NE/L009524/1
Publisher:
Elsevier
Journal:
Trends in Microbiology More from this journal
Volume:
25
Issue:
5
Pages:
336–348
Publication date:
2017-04-01
Acceptance date:
2017-03-03
DOI:
EISSN:
1878-4380
ISSN:
0966-842X
Keywords:
Pubs id:
pubs:685556
UUID:
uuid:8fad033e-7fb7-4546-b9b9-bfa5e6316ecd
Local pid:
pubs:685556
Source identifiers:
685556
Deposit date:
2017-03-14

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