Journal article icon

Journal article

Informing efficient randomised controlled trials: Rxploration of challenges in developing progression criteria for internal pilot studies

Abstract:

Objectives

Designing studies with an internal pilot phase may optimise the use of pilot work to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed decision or ‘progression’ criteria at the juncture between the internal pilot and main trial phases provides a valuable opportunity to evaluate the likely success of the main trial and optimise its design or, if necessary, to make the decision not to proceed with the main trial. Guidance on the ap...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1136/bmjopen-2016-013537

Authors


More by this author
ORCID:
0000-0001-5477-2418
Williamson, PR More by this author
O'Connell Francischetto, E More by this author
Metcalfe, C More by this author
Expand authors...

Contributors

Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Contributor
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
7
Issue:
2
Pages:
e013537
Publication date:
2017-02-17
Acceptance date:
2017-01-19
DOI:
EISSN:
2044-6055
ISSN:
2044-6055
Pubs id:
pubs:683784
URN:
uri:8faa5d79-1209-4505-88d4-954e4f1cd487
UUID:
uuid:8faa5d79-1209-4505-88d4-954e4f1cd487
Local pid:
pubs:683784

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP