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Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.

Abstract:

Inappropriate osteoclast activity instigates pathological bone loss in rheumatoid arthritis. We have investigated how osteoclasts generate sufficient ATP for the energy-intensive process of bone resorption in the hypoxic microenvironment associated with this rheumatic condition. We show that in human osteoclasts differentiated from CD14(+) monocytes, hypoxia (24 h, 2% O2 ): (a) increases ATP production and mitochondrial electron transport chain activity (Alamar blue, O2 consumption); (b) incr...

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Publication status:
Published

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Publisher copy:
10.1002/path.4159
Journal:
Journal of pathology More from this journal
Volume:
229
Issue:
5
Pages:
755-764
Publication date:
2013-04-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417

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