Journal article
The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins
- Abstract:
-
We have shown that a lentiviral vector (rSIV.F/HN) pseudotyped with the F and HN proteins from Sendai virus generates high levels of intracellular proteins after lung transduction. Here, we evaluate the use of rSIV.F/HN for production of secreted proteins. We assessed whether rSIV.F/HN transduction of the lung generates therapeutically relevant levels of secreted proteins in the lung and systemic circulation using human α1-anti-trypsin (hAAT) and factor VIII (hFVIII) as exemplars. Sedated mic...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 1.3MB)
-
- Publisher copy:
- 10.1038/s41434-018-0025-8
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Gene Therapy Journal website
- Volume:
- 25
- Pages:
- 345–358
- Publication date:
- 2018-07-18
- Acceptance date:
- 2018-05-16
- DOI:
- EISSN:
-
1476-5462
- ISSN:
-
0969-7128
- Pmid:
-
30022127
- Source identifiers:
-
891311
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:891311
- UUID:
-
uuid:8f9ee9cc-4ace-4a0f-9b81-21ec9bf7bb59
- Local pid:
- pubs:891311
- Deposit date:
- 2019-06-18
Terms of use
- Copyright holder:
- Paul-Smith et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is published with open access.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record