- Abstract:
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We have shown that a lentiviral vector (rSIV.F/HN) pseudotyped with the F and HN proteins from Sendai virus generates high levels of intracellular proteins after lung transduction. Here, we evaluate the use of rSIV.F/HN for production of secreted proteins. We assessed whether rSIV.F/HN transduction of the lung generates therapeutically relevant levels of secreted proteins in the lung and systemic circulation using human α1-anti-trypsin (hAAT) and factor VIII (hFVIII) as exemplars. Sedated mic...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.3MB)
-
- Publisher copy:
- 10.1038/s41434-018-0025-8
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Gene Therapy Journal website
- Volume:
- 25
- Pages:
- 345–358
- Publication date:
- 2018-07-18
- Acceptance date:
- 2018-05-16
- DOI:
- EISSN:
-
1476-5462
- ISSN:
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0969-7128
- Pubs id:
-
pubs:891311
- URN:
-
uri:8f9ee9cc-4ace-4a0f-9b81-21ec9bf7bb59
- UUID:
-
uuid:8f9ee9cc-4ace-4a0f-9b81-21ec9bf7bb59
- Local pid:
- pubs:891311
- Copyright holder:
- Paul-Smith et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is published with open access.
Journal article
The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins
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